In 2004, Portland, Ore.-based husband and wife Tim O’Leary, founder and CEO of creative shop Respond2, and Michelle Cardinal, founder and CEO of media agency Cmedia, decided to formally tie the knot between their businesses, too. The merger resulted in the creation of R2C Group, an independent agency that specializes in direct response TV marketing and “transactional brand building,” explained Cardinal. Now, more than a decade later, R2C has over 220 employees, four offices (in Portland, San Francisco, Pennsylvania and Rhode Island), and counts a variety of ecommerce brands like Peloton Cycle, Texture, Leesa and Chewy.com as clients. “The millennial CEOs [who run these companies] don’t have old ideas about advertising because they come from a digital background where ROI is really important,” said Cardinal, “so when they get into…